Endotoxins:
Endotoxin is a pyrogenic compound which increases body temperature like,Fever.
Every gram -ve bacteria produce Endotoxin s when cell has undergone lysis it leads to panic fever.
Why E-coli is suitable for Endotoxin extraction that E-coli contained more Endotoxins campare to other gram -ve bacteria s i.e Pseudomonas, klebsiella,Nisseria, Clostridium etc. In E-coli more toxic activity of Lipid -A is associated with polysacharides.
Cell structure:
Lipopolysaccharides (LPS), also known as lipoglycans and endotoxins, are large molecules consisting of a lipid and a polysaccharide composed of O-antigen, outer core and inner core joined by a covalent bond; they are found in the outer membrane of Gram-negative bacteria.
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